CRYOGENIC TREATMENT AT THE CENTER OF MEDICINE AND DENTISTRY EDELWEISS

(LLC "Alexandria 24")

Address: 1 Proletarsky prospekt,

Moscow, 115522.

Working hours: seven days a week 

from 9.00 to 21.00

Phone numbers: 8(495)655-67-70 

8(901)380-64-00

ABOUT OUR CENTER

Our Edelweiss Center for Medicine and Dentistry is located in the Moskvorechye-Saburovo district of Moscow, a 15-minute walk from Kashirskaya metro station.

We offer a full range of dental and cryogenic treatment services at affordable prices.

The Edelweiss Center for Medicine and Dentistry was established more than 10 years ago on the basis of the former Alexandria 24 clinic, in which the main focus was emergency and round-the-clock dental care for patients. Due to the expansion of the types of services and the treatment used, we have developed to the level of a medical center. In it, we provide a wide variety of services to the public, the main areas of our center are dentistry and cryosurgical treatment.

Scientific supervisors and founders of the cryogenic treatment room at the Edelweiss Center for Medicine and Dentistry: MD, Professor, Department of Pediatric Surgery, Russian National Research Medical University V.V. Shafranov; Otorhinolaryngologist, Head. cryogenic treatment room GKB №60 Z.V. Kalmykova; Surgeon-oncologist V.V. Korsun.

Cryosurgery is a highly effective treatment for a number of benign and malignant neoplasms and various diseases. The number of patients with benign and malignant skin growths is steadily increasing from year to year, all over the world. Cryosurgical treatment is used for many superficial neoplasms, both in common pathology and in pathology for which cryosurgical treatment is etiotropic and pathogenetically justified. In particular, it is the treatment of basal cell carcinoma, keloid scars, neoplasms associated with the human papillomavirus, common superficial neoplasms, etc.

Among the various malignant epithelial neoplasms of the skin, basal cell carcinoma (basal cell carcinoma) prevails by a wide margin from all others. The typical localization of basal cell carcinoma is usually on the head, up to 80-90% of cases on the face. This location of the tumor creates impressive cosmetic damage, locally stimulating tumor growth, leads to disfiguring destruction of the nose, jaw, orbit and auricles, and causes additional psychoemotional suffering of the patient. The optimal choice of treatment in this case will be cryosurgical treatment, which we can offer in the cryogenic treatment room of our Edelweiss Center for Medicine and Dentistry.

PRINCIPLES OF CRYOSURGICAL TREATMENT

Histologically, cryofreezing causes ischemia and necrosis by direct cell damage, thrombosis, and microcirculatory insufficiency. Factors contributing to the irreversibility of cell destruction during freezing include significant cell dehydration, leading to a sharp increase in electrolyte concentration, mechanical damage to cell membranes by ice crystals, as well as compression of cell bodies by these crystals, denaturation of phospholipids in cell membranes, cessation of intracellular fluid mobility, and the development of a focus of ischemic necrosis as a result of stopping blood flow in the volume of frozen tissue.

The faster the cooling, the lower the temperature reached, and the slower the thawing, the more cells die.

Other factors also influence the degree of tissue damage. Different cells, tissues, and organisms have different intrinsic sensitivity to cold: melanocytes and basal cells, as well as bacteria, die easily, while fibroblasts, collagen, nerve tissue, and blood vessels are relatively immune to cold injury, which causes the main cosmetic advantages of cryosurgery - minor effects on connective tissue and relatively small damage to blood vessels and nerves. The absence of damaging effects on the walls of large vessels and nerve trunks allows cryodestruction in the immediate vicinity of these neoplasms.

Thus, the intensity of cryodestruction depends on the individual tissue's resistance to cold, its temperature and cooling rate, exposure, as well as the rate and time of tissue thawing after it.

The main advantage of cryodestruction is the phenomenon of organotypic regeneration, that is, healing without a scar, or healing with a mosaic regenerate, including areas of organotypic and scar tissue.

An important and distinctive factor in cryosurgical treatment is the immunomodulatory effect of stimulating specific antitumor, antiviral, antimicrobial, and antifungal immunity.

CRYOSURGICAL TREATMENT METHODS

CRYODESTRUCTION APPLICATION

Cryodestruction is performed by a filler-type device, in which liquid nitrogen is located in its tank and cools the tip.

If a cryoapplicator is used, it is cooled in a special container with liquid nitrogen, after which the cryoapplicator is applied to the destruction area.

The exposure depends on the size of the tumor, but averages 2-3 minutes, less often up to 5-7 minutes.

CRYODESTRUCTION SPRAY

Cryodestruction is performed using a portable serial device. If necessary, before the operation, select a tube (fluoroplastic funnel) corresponding to the diameter of the tumor.

Then the tube is placed on the tumor and a stream of liquid nitrogen is directed into it.

Cryotherapy is performed for 2-10 minutes.

MICROWAVE RADIATION + CRYODESTRUCTION

Pre-exposure to a microwave field is used to prolong the thermal (metabolic) barrier and structural resistance, i.e. to increase the volume of cryodestruction. Ultrashort radio waves are commonly divided into meter, decimeter, centimeter, millimeter, and submillimeter (micrometer) waves. Waves with a wavelength of λ from 1 cm to 10 cm. and a frequency of v from 3 GHz to 30 GHz – centimeter band (CMB).

Immediately before the operation, the surgical area is irradiated with a microwave field (CMB range) for 5-10 minutes.

With microwave cryodestruction, it is possible to obtain a cryodestruction zone 4-6 times larger than the "pure" cryodestruction zone.

CRYODESTRUCTION + QUANTUM EFFECTS

Multifactorial quantum exposure is performed after cryodestruction, usually several exposure sessions are performed.

Multifactor sources of electromagnetic radiation use, at a minimum, a permanent magnetic field, a red light source, a pulsed source of infrared radiation and a source of low-intensity infrared laser radiation.

The global burden of malignant diseases is gradually and continuously increasing. In most cases, patients need new radical and palliative approaches in the treatment of malignant diseases, which leads to an improvement in the quality of life and an increase in the life expectancy of patients.

There are a large number of borderline precancerous diseases, benign neoplasms, in the absence of treatment or inadequate treatment of which their malignancy is possible – that is, the acquisition by cells of pathologically altered body tissue and even normal body cells of the properties of a malignant tumor. Malignancy is based on violations of the processes of cell differentiation and proliferation.

Cryosurgical interventions are one of the promising directions in the treatment of a number of diseases, including malignant ones, especially due to the development of new technical capabilities for delivering cryoagent directly to the site of cryodestruction, visualization of the cryodestruction process itself, the possibility of its programming and the development of such areas of medicine as cryoimmunology.

It is extremely important that cryosurgical treatment of these diseases be performed by specialists in the field of medicine, surgeons, oncologists who have received special training in cryomedicine and, in particular, cryosurgical treatment.

In addition, the clinical experience of doctors who use cryosurgical treatment of various diseases in their practice is important for conducting competent preoperative screening of patients, choosing cryosurgical treatment methods and tactics after surgery, and follow-up of patients.

Cryosurgical interventions should be performed in specialized licensed medical institutions that provide medical care to patients, primarily with surgical diseases.

Good cosmetic effect (usually absence of scars and other defects).

Good long–term results of the operation (as a rule, the minimum number of recurrences).

The anesthetic effect of the operation itself (usually there is no need to use additional anesthesia methods).

The hemostatic effect of the operation itself (as a rule, without bleeding and without pronounced hemorrhagic discharge).

The immunomodulatory effect of the operation itself and the ablasticity of the method (prevention of relapses or progression of the disease, often in combination with the use of immunocorrection drugs).

The absence of intoxication and the good tolerability of the operation itself are performed on an outpatient basis (these operations can be performed without hospitalization or in a one-day hospital).

Long-term healing of the postoperative wound (at least 10-15 days).

It is possible to develop prolonged (for several days) perifocal edema (edema of surrounding tissues).

It is possible to use repeated cryodestruction sessions in the area of the postoperative wound (mainly for large and voluminous neoplasms).

It is possible to develop an unexpressed hypopigmentation in the area of the postoperative wound (it may disappear after a long time – at least several months).

Few contraindications are mainly related to concomitant diseases, in which an excessive reaction to cold and/or a slowdown in healing processes are possible.

Relative contraindications: cold intolerance; collagen or autoimmune diseases; concurrent treatment with immunosuppressive drugs; pyoderma gangrenosa; multiple myeloma; Raynaud's disease; Burger's disease.

Absolute contraindications: rapidly progressing sarcoma; disagreement with possible pigmentation changes; negative perception of cryotherapy.

The cryosurgical method is one of the competitive methods of treating oncological diseases, as it is highly effective, ablastic, bloodless, painless, with an immunomodulatory effect, with a good cosmetic effect, with a good prognosis and is easily tolerated by patients.

The cryogenic treatment method in the presented variants does not cause intoxication and is accompanied by minimal operational risk, it is applicable even with contraindications to traditional surgical treatment.

The simplicity of the cryosurgical treatment method allows it to be widely used in daily practice in both a cryotherapy room and an operating room.

The use of cryosurgery is very effective, allows you to achieve a positive result and is a new technology, as well as an alternative to traditional methods of treatment.

The Edelweiss Center for Medicine and Dentistry offers a wide range of cryosurgical treatment services for various diseases:

Benign neoplasms of various localization and prevalence (papillomas, hemangiomas, nevi, dermatofibromas, acanthomas, keratomas, epidermal cyst, cutaneous horn, etc.);

Malignant neoplasms of various localization and prevalence (basal cell carcinoma);

Viral infections of the skin and mucous membranes (molluscum contagiosum, warts, warts);

Keloid and hypertrophic scars;

Otorhinolaryngic diseases;

Our center provides cryotherapy for diseases such as solar lentigo, alopecia areata, etc.

Cryocosmetological procedures are performed: cryomassage and cryopilling.